Director, Medicinal Chemistry - Boston

About Frontier Medicines

Frontier Medicines, located in South San Francisco, CA and Boston, MA, is a precision medicine company that has pioneered a powerful discovery and development platform designed to generate medicines against disease-causing proteins previously considered undruggable. We are deploying our technologies in chemoproteomics, covalent drug discovery, and machine learning to develop a pipeline of groundbreaking medicines against the most important drivers of disease. Frontier has been recognized as a Fierce 15 company and a C&EN Start-Up to Watch. Our lead program targets both the active and inactive forms of KRASG12C, a validated driver in a number of cancers that until recently has been undruggable. Our pipeline embodies our vision of boldly advancing science to defeat disease, starting with cancer.

About the Role

Frontier Medicines is seeking a highly motivated individual for a newly created Director role in Medicinal Chemistry in Frontier’s Boston office. The successful candidate will lead a team of internal and external medicinal chemists to optimize and advance novel compounds into clinical development. As a member of project teams and potential project team leader, you will oversee development of compounds for potency, DMPK, and pharmacology.

Key Responsibilities
  • Discover and advance novel small molecule drugs into clinical development
  • Lead, mentor, develop, motivate, and inspire a team of reporting scientists to create a collaborative, lab-based culture
  • Apply organic and medicinal chemistry skills in the design and synthesis of novel small molecules as potential drug candidates
  • Contribute to overall corporate medicinal chemistry strategy
  • Guide biological testing, ADME characterization, and other lead profiling assays; proactively propose new strategies and new target molecules to improve key drug attributes
  • Proactively help manage external chemistry efforts, providing synthetic expertise in a collaborative fashion
  • Regularly summarize results and provide progress updates to the chemistry and cross-functional project teams
  • Contribute to the writing of patent applications, study reports, and scientific publications
  • Assist in choosing new biological targets
  • Ph.D. in organic or medicinal chemistry with at least 12-15 years of relevant experience in a biotech or pharma setting
  • Masters degree with 15-20 years relevant experience in a biotech or pharma setting
  • Demonstrated success in delivering multiple novel agents into clinical development
  • Extensive project leadership experience bringing teams through lead optimization and selection of development candidates
  • Demonstrated track record of patents and publications in medicinal chemistry
  • Intellectual fearlessness and strong innovative streak
  • Ability to work with and manage multifunction teams
  • Extensive working knowledge of modern medicinal chemistry and drug discovery techniques (e.g., fragment and structure-based drug design, computational chemistry, multi-parametric optimization of bioactivity/physicochemical/ADME properties)
  • Experience in the discovery of covalent drug molecules very highly preferred
  • Self-motivated and enthusiastic; fast learner who can identify the core project challenges and expeditiously change course as required in a fast-paced organization
  • Team player who will be able to collaborate effectively in a multi-disciplinary team environment
  • A commitment to excellence, maintaining detailed records and having superb data organization skills
  • Exceptional oral communication and writing skills
  • Legally authorized to work in the US

To apply, please send your resume to