Precision Pipeline
FMC-220:
Restoring the guardian of the genome
FMC-220
FMC-220 is a covalent activator of p53 Y220C that is designed to selectively restore p53 tumor suppressor function. The covalent mechanism of action provides the unique ability to deliver persistent p53 activation resulting in tumor cell death.
The TP53 tumor suppressor gene is the most frequently mutated gene across all human cancers. TP53 loss-of-function mutations, which confer a poor prognosis in many cancers, lead to destabilization, aggregation, and loss of p53 protein function. The TP53 Y220C mutation is among the more commonly seen TP53 mutations, occurring in 1-2% of human cancers including ovarian, lung, breast, colorectal and other cancer types.